[SHORT REPORTS]Age-Related Changes in Vasoconstrictive and Sudomotor Responses to the Skin Sympathetic Nerve Activity in Humans

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概要

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• Skin sympathetic nerve activity (SSNA) was microneurographyically recorded in five young men and a 70-year-old man to investigate age-related changes in effector response, i.e., the vasoconstriction and sudomotor responses. The relationship between the vasoconstrictor component of SSNA and reductions in skin blood flow by laser Doppler flowmetry was examined as well as the relationship between sudomotor component of SSNA and sweating, both at rest and while undergoing various stimuli. A significant logarthmic correlation between the amplitude of integrated SSNA and the reduction in skin arithmic correlation btween the amplitude of integrated SSNA and the reduction in skin blood flow, and a significant linear correlation was found between the amplitude of SSNA and the slope of sweat expulsion in all young subjects, whereas these relationships were diminished in the dlderly man. We concluded that this age-related difference can be partially attributed to reduced vascular dopliance in the elderly, and in part to hypofunction of sweat glands.

• 名古屋大学の論文

著者

• MANO Tadaaki

  Tokai Central Hospital

• Sugenoya Junichi

  Department Of Physiology Aichi Medical University School Of Medicine

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• [SHORT REPORTS]Age-Related Changes in Vasoconstrictive and Sudomotor Responses to the Skin Sympathetic Nerve Activity in Humans

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