グルタチオンの安定性に及ぼす微量元素の影響と安定化

概要

論文の詳細を見る
Glutathione (GSH) was combined with trace elements in infusion solution for total parenteral nutrition. The effects of the trace elements (copper, zinc and selenium) on the stability of GSH, and the stabilization of GSH by protamine sulfate (PT) and ascorbic acid (AC) were studied by reversed-phase high-performance liquid chromatography using 4-(amino-sulfonyl)-7-fluoro-2, 1, 3-benzoxadiazole (ABD-F). The contents of GSH decreased in the presence of zinc, copper, and selenium, in that order. In particular, 14% of GSH remained after 10 minutes at 25℃ in the presence of 5μM of selenium. The contents of GSH decreased with an increase in the concentration of selenium. GSH was stabilized by PT or AC in the presence of trace element. When 5μM of cupric sulfate was added to the GSH solution after 20 minutes, 39.5% of GSH remained. On the other hand, 70.6% of GSH remained under the same conditions in the presence of 10mg of AC per ml.
日本医療薬学会の論文
1990-06-20