院内製剤リン酸クリンダマイシンローションの安定性

概要

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Topical clindamycin is used in the treatment of acne vulgaris at this time. In hospital pharmacy, 1% clindamycin phosphate lotion for acne vulgaris is prepared from the injectable form of clindamycin phosphate dissolved in the hydro alcoholic vehicle. Stability of the preparation and 1% clindamycin phosphate aqueous solution was studied at 5° and 2° for 180 day. The pH of the sample was observed along with a periodical visual inspection. The amount of clindamycin phosphate in solution was determined by reversed-phase ion-pairing high-performance liquid chromatography (HPLC) with UV detector at 210 nm. 1% clindamycin phosphate lotion maintained 92% of its activity during the period of 180 days at 5°, and 88% at 25°. 1% clindamycin phosphate aqueous solution retained 91% of its activity over the period of 180 days at 5°, and 90% at 25°. As a primary degradation product of clindamycin phosphate in solution, lincomycin-2-phosphate was found in small amount. 1% clindamycin phosphate lotion is relatively stable and good for more than 180 days at 5°.
日本医療薬学会の論文
1985-12-20