抗てんかん薬服用患者の血中薬物濃度測定値

概要

論文の詳細を見る
Serum levels of 10 epileptic patients (261 samples) receiving in our hospital oral antiepileptic drugs such as phenytoin (PHT), Phenobarbital (PB), carbamazepine (CBZ) and sodium valproate (VPA) were determined by enzyme immunoassay method. The correlation between dosage and serum level of PHT was observed (r=0.554) to some extent. The correlation between dosage and serum level of PB was significant (r=0.740). Furthermore, in some symptoms subject to the combination with PHT, the serum levels were almost in effective therapeutic range, showing high correlation and high value of linear regression. CBZ did not show any dose dependency, and the slope of its linear regression was as low as 0.082. VPA serum level was not equivalent to the value as reported in the previous papers. This is due probably to a reduction of half-life period and an elevation of metabolism resulting from enzyme auto-induction caused by other antiepileptic drugs received. Hence VPA serum level may be lowered.
日本医療薬学会の論文
1985-08-20