高カロリー輸液におけるβ-ラクタム系抗生物質配合変化の検討

概要

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A study on the stability of three β-lactam antibiotics (ampicillin, sulbenicillin, and cephalotin at an initial concentration of 4mg per ml) in four kinds of IVH solution and 5% dextrose in water was carried out to determine the apparent first-order degradation constants at room temperature. In contrast to the stability of cephalotin, ampicillin and sulbenicillin were inactivated with the degradation constant of 0.006 to 0.028h^-1 and 0.007 to 0.015h^-1, respectively. In addition, Pharmacokinetic studies were made on two healthy subjects following 8-hour continuous infusion of ampicillin in 5% dextrose in water (2g per 500ml), which had the largest degradation constant. The observed values were lower than those predicted on the basis of individual kinetic parameters, indicating that the decrease of infusion rate due to ampicillin inactivation have caused the fall in the serum drug level.
日本医療薬学会の論文
1982-10-20