塩酸ヒドララジン散の配合変化と含量変化
スポンサーリンク
概要
- 論文の詳細を見る
Incompatibility of hydralazine hydrochloride with 22 other drugs was studied under the medium conditions (20°, RH 75%) and the worst conditions (30°, RH 92%). Change in appearance was observed immediately after mixing and 1, 2, 4, 7, 10 and 14 days after. Two weeks after mixing, coloring, moistening and other changes were observed in 18 mixtures under the medium conditions and in 21 mixtures under the worst conditions. The marked changes that made unpracticable the use of the products occurred in 1 mixture under the medium conditions and in 14 mixtures under the worst conditions. On the 9 mixtures with marked changes, quantitaive determination of hydralazine was made 1, 2, 4, 7, 10 and 14 days after their mixing. Hydralazine content, as a result, reduced in 4 mixtures under the medium conditions and in all mixtures under the worst conditions. It should, therefore, be recommended that hydralazine preparations are not mixed with antacids before their administration.
- 日本医療薬学会の論文
- 1980-02-20