フトラフールE顆粒の配合変化
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概要
- 論文の詳細を見る
Compatibility of enteric-coated Futraful E Granules (FTEG) with 60 commercial preparations was investigated. In combination with ETEG, changes in appearance (wetness, coagulation, coloration and liquefaction) under the worst condition (30°, RH 92%) were observed in only 3 of the 60 preparations : neophylline, theocolin and sodium bicarbonate. In thin-layer chromatography, decomposed compounds produced in combination of FTFG with the 3 preparations were identified as 5-fluorouracil. In the dissolution test, FTEG was not dissolved in 1st fluid (J.P.IX) in the same combination. Therefore, the combination of FTEG with 2 of the 3 preparations should be avoided, but the combination with the remaining 57 preparations is possible if attention is paid to packaging, duration of administration and other conditions.
- 日本医療薬学会の論文
- 1979-11-20