スルピリン水溶液の着色におよぼす塩化リゾチームと酸の影響および着色機構について

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概要

• 論文の詳細を見る

• The color of sulpyrine solutions grew in parallel with the concentration of sulpyrine and by addition of lysozyme chloride. The pH values of these solutions rose with time (t) as : pH = k log t. However, when acidic compounds were added to them, the rate of the change of pH values was decreased, and the coloration was controlled. In this case, k values as the rate constant were changed at about pH 2 and 2.6-3.2, and light color developed in the process of rising of pH values of the solutions above 2.6-3.2. These results were contrary to the properties of sulpyrine observed in decomposition to 4-methylaminoantipyrine in known solutions. Aldehyde was detected from coloring on the spot in thin-layer chromatography by Schiff's reagent. Therefore, it was considered that the colored matter was formylic compounds produced from residual sulpyrine without change at fourth position.

• 日本医療薬学会の論文
• 1977-11-20

著者

• 田中 尚純

  甲府共立病院薬剤部

関連論文

• スルピリン水溶液の着色におよぼす塩化リゾチームと酸の影響および着色機構について
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