注射剤の溶血性について

概要

論文の詳細を見る
The study of injectable solutions was focused on hemolytic effects of parenteral solutions. The experiment was made after the method of Akaishi et al., the Tohoku University School of Medicine. 0.1 ml of whole human blood containing anticoagulant was added to 1 ml of parenteral solution warmed up to 37゜ for about 2 minutes, and the solution was centrifugalized for 5 minutes at the speed of 2,000 rpm. The degree of hemolytic effect was examined macroscopically. About 50% of 161 kinds of examined injectable solutions proved to be hemolytically positive, consisting of + 12.4%, ++ 19.3%, +++ 8.7%, ++++9.9%; remaining solutions, composing 49.7%, were negative. The hemolytic effect was noted more often in intramuscular preparations than in intravenous; most of the analgesic-antipyretics and antihistamines showed positive reactions. This study also indicated that the hemolytic effect varies with types of solvents, concentration and mixing of solutions.
日本医療薬学会の論文