Mode of Action of Nonsteroidal Ecdysone Agonists, Diacylhydrazine Analogs(Society Awards 2005)

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概要

• 論文の詳細を見る

• The binding affinity of insect molting hormone agonists, N-tert-butyl-N, N'-diacylhydrazine (DAH) analogs, against the molting hormone receptor proteins (EcR/USP) was measured. For the lepidopteran Chilo suppressalis, the receptor-binding activity of DAH analogs correlated linearly with their molting hormonal activity (in vitro) and insecticidal activity (in vivo). The binding activity of DAH analogs of C. suppressalis EcR/USP was higher than that of the dipteran Drosophila melanogaster EcR/USP. The binding activity of EcR/USP changed little when USP was exchanged between C. suppressalis and D. melanogaster. These results suggest that the selective toxicity of DAH analogs toward Lepidoptera is caused by the difference in the structure of EcR, not by that of USP.

• 日本農薬学会の論文
• 2005-08-20

著者

• Minakuchi Chieka

  Department Of Biology University Of Washington

関連論文

• Insect juvenile hormone action as a potential target of pest management
• Mode of Action of Nonsteroidal Ecdysone Agonists, Diacylhydrazine Analogs(Society Awards 2005)

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