3 線維芽細胞のサイトカイン分泌と,血液細胞の分化増殖に対するベスナリノンの影響 (第461回大阪歯科学会例会)
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Vesnarjnone (3, 4-dihydro-6-[4-3, 4-dimethoxybenzoyl-1-piperazinyl]-2 (1H)-quinolinone) is an jnotropic agent used in treating congestive heart failure. However, its clinical application is limited because it has agranulocytosis as a sideeffect. To clarify the mechanism of vesnarinone-induced agranulocytosis, we investigated the effects of vesnarinone on ceramide-related cell growth, apoptosis and cytokine secretion. In HL-6O cells, vesnarinone increased cell differentiation and apoptosis when assessed by NBT (nitroblue tetrazolium) reducing ability and DAPI staining. It also in-creased generation of ceramide. We also found both vesnarinone and ceramide enhanced TNF α-induced IL-8 secrelion from HL-6O cells, and that ceramjde significantly inhibited TPA-induced IL-6 secretion from HFL-1 cells. These results suggest that vesnarjnone-induced agranulocytosis caused both the inhibition of growth factor secretion from fibroblasts, and the enhancement of cell differentiation and apoptosis via ceramide signalling in hematopoietic cells.
- 大阪歯科学会の論文
- 1998-12-25
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- 3 線維芽細胞のサイトカイン分泌と,血液細胞の分化増殖に対するベスナリノンの影響 (第461回大阪歯科学会例会)