5 三叉神経系におけるアミノ酸受容体の役割 (第436回 大阪歯科学会例会)

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概要

• 論文の詳細を見る

• We examined the expression of the γ1 and γ2 subunit mRNAs of the γ-aminobutyric acid (GABA)_A receptor in the trigeminal ganglion (TG). Most TG cells expressed both γ1 and γ2 mRNAs simultaneously. Furthermore, expression of the γ1 subunit in the primary sensory afferents were confirmed at the protein level by immunohistochemistry using antiserum against the γ1 subunit. These findings indicate that primary sensory afferents receive GABAergic input axo-axonically via GABA_A receptors expressing γ1 and γ2 subunits. We demonstrated that a few neurons projecting to the thalamus in the TNC (trigeminal nucleus caudalis) were labeled by antiserum that recognizes the GluR1 and GluR2/3 subunits of the AMPA type glutamate receptor. However, expression of the γ1 and γ2 subunits of the GABA_A receptors indicated that several neurons projecting to the thalamus in the TNC receive GABAergic input via GABA_A receptors that at least contain γ1 and γ2 subunits.

• 大阪歯科学会の論文
• 1994-10-25

著者

• 金銅 英二

  大阪歯大・大学院・歯科麻酔

関連論文

• 5 三叉神経系におけるアミノ酸受容体の役割 (第436回 大阪歯科学会例会)

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