2 ヒト舌扁平上皮癌に対するモノクローナル抗体の作製および免疫組織化学的特性 (第410回 大阪歯科学会例会)

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概要

• 論文の詳細を見る

• Formalin resistant monoclonal antibodies (MoAbs) against squamous cell carcinoma (SCC) were produced using as an immunogen deparaffinized tissue from formalin-fixed, paraffin-embedded block of human tongue carcinoma. Electrofusion (E) and polyethylene glycol fusion (P) were performed and three MoAbs (IgM, kappachain), E 8, P 53 and P 54 were isolated and characterized. E 8 and P 54 recognized the cytomembrane of various normal and neoplastic oral epithelial cells. The staining patterns of P 53 were similar to those of several keratin MoAbs, and immunoblotting assays showed multiple keratin bands of 40-68kDa. All three MoAbs reacted strongly with well differentiated SCC. These antibodies may provide pathologists with new insights into diagnostic markers.

• 大阪歯科学会の論文
• 1992-02-25

著者

• 堀 晋作

  大阪歯大・臨床歯研

• 堀 晋作

  大阪歯大・臨床歯科研

関連論文

• I-F-P-17 ヒト舌扁平上皮癌に対するモノクローナル抗体対応抗原の超微局在
• 2 ヒト舌扁平上皮癌に対するモノクローナル抗体の作製および免疫組織化学的特性 (第410回 大阪歯科学会例会)

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