3 ラットにおける抗精神病薬ハロペリドールの顎下腺唾液,血液および脳内濃度の比較(第490回大阪歯科学会例会)

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概要

• 論文の詳細を見る

• Haloperidol is one of the most widely prescribed of conventional antipsychotic drugs. We compared drug concentrations in the saliva, blood and brain, after intravenous administration (0.25 mg/kg) in rats. We also investigated immunohistochemical localizations of the haloperidol. There was a significant correlation between the level of salivary haloperidol in the blood and that in the brain (p<0.01). The correlation coefficient between levels in the saliva and the brain (r=0.56-0.71) was greater than that between the blood and the brain (r=0.37-0.59). The striated duct within the gland was strongly positive for haloperidol. This study supports the concept that salivary haloperidol concentration may be used effectively for therapeutic drug monitoring.

• 2003-12-25

著者

• 江藤 賢治

  大阪歯大・大学院

関連論文

• 3 ラットにおける抗精神病薬ハロペリドールの顎下腺唾液,血液および脳内濃度の比較(第490回大阪歯科学会例会)

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