Synergistic Inhibition of the Growth of Suspension Cultured Tobacco Cells by Simultaneous Treatment with Cadmium and Arsenic in Relation to Phytochelatin Synthesis

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概要

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• Simultaneous treatments with Cd and arsenic (arsenite and arsenate) led to the synergistic growth inhibition of tobacco (Nicotiana tabacum cv. BY-2) cells. Cd contents in cells increased by co-treatment with arsenic for 24h. The amount of total phytochelatins (PCs) per unit of Cd in the cells treated with Cd and arsenate was lower than that in the cells treated with Cd alone. Simultaneous treatments with Cd and arsenic promoted the induction of the biosynthesis of (γ-Glu-Cys)_2-Gly and inhibited the induction of the biosynthesis of (γ-Glu-Cys)_3-Gly and (γ-Glu-Cys)_4-Gly, compared with the treatment with Cd alone. Consequently, since the inhibition of PC biosynthesis led to the increase of the cellular concentration of putative ionic (=toxic) Cd, cell growth was inhibited synergistically by simultaneous treatments with Cd and arsenic. In addition, based on the results showing that buthionine sulfoximine increased the sensitivity to arsenite and arsenate, and that PC biosynthesis was induced by treatment with arsenite or arsenate, it is suggested that glutathione and/or its metabolic products such as PCs are involved in arsenic tolerance.

• 社団法人日本土壌肥料学会の論文

著者

• Yasuda Kaori

  Department Of Applied Biology And Chemistry Faculty Of Applied Bioscience Tokyo University Of Agricu

• Takenaga H

  Department Of Applied Biology And Chemistry Faculty Of Applied Bioscience Tokyo University Of Agricu

• Takenaga Hiroshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture

• Nakazawa R

  Tokyo Univ. Agriculture Tokyo Jpn

• Nakazawa Ryoji

  Department Of Agricultural Chemistry Faculty Of Agriculture Tokyo University Of Agriculture

• Ikawa Masayuki

  Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agri

• Ikawa Masayuki

  Department Of Applied Biology And Chemistry Faculty Of Applied Bioscience Tokyo University Of Agricu

関連論文

• Interactions between Cadmium and Several Heavy Metals in the Activation of the Catalytic Activity of Phytochelatin Synthase
• Synergistic Inhibition of the Growth of Suspension Cultured Tobacco Cells by Simultaneous Treatment with Cadmium and Arsenic in Relation to Phytochelatin Synthesis
• The Parameterization of All Robust Stabilizing Simple Repetitive Controllers
• Synthesis and Biological Activities of 1α,4α,25- and 1α,4β,25-Trihydroxyvitamin D3 and Their Metabolism by Human CYP24A1 and UDP-Glucuronosyltransferase

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