Aneugenic effects of carbendazim and griseofulvin as assayed in the in vitro maturation system of mouse oocytes
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概要
- 論文の詳細を見る
To evaluate the aneugenic effects of carbendazim (MBC) and griseofulvin (GF) on meiosis, we cultured mouse oocytes, allowing them to mature in vitro in the presence of MBC and GF. The incidence of hyperploidy was significantly increased in oocytes cultured with 0.6μg/mL or higher concentration of MBC, while the incidence of diploidy was significantly increased in oocytes cultured with 1 or 3 μg/mL of GF. To investigate the stage-specific effects of these chemicals during meiotic progression, the oocytes were exposed to chemicals for the initial 7 h or final 8 h of the culture. Both MBC and GF were found to effectively induce numerical aberration during the final half of the culture. Thus, in vitro maturation of mouse oocytes is a useful model for the detection of chemically induced aneuploidy and for the detection of stage-specific effects of chemicals during meiosis.
- 日本環境変異原学会の論文
- 2004-12-20
著者
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TORIYAMA Masaru
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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森 誠
静岡大学 農学部 応用生物化学科
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MORI Makoto
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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笹浪 知宏
静岡大学 農学部 応用生物化学科
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SASANAMI Tomohiro
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Mori Makoto
Faculty Of Agriculture Shizuoka University
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MIZUHASHI Fukutaro
Biosafety Research Center, Foods, Drugs and Pesticides
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TANAKA Ryota
Biosafety Research Center, Foods, Drugs, and Pesticides (An-Pyo Center)
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Toriyama Masaru
Department Of Applied Biological Chemistriy Faculty Of Agriculture Shizuoka University
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Mori Makoto
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Tanaka Ryota
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Tanaka Ryota
Biosafety Research Center Foods Drug And Pesticides
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Sasanami Tomohiro
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Mori Makoto
Department Of 1st Oral Surgery School Of Dentistry Aichi-gakuin University
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Mizuhashi Fukutaro
Biosafety Research Center Foods Drugs And Pesticides
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Mizuhashi Fukutaro
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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