第26回大会シンポジウム 癌原性物質検出系としてのセルトランスフォ-メ-ション試験の現状

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概要

• 論文の詳細を見る

• Cell transformation assays are in vitro assays that measure the ability of chemicals, viruses or specific genes to alter the cellular phenotypes that are associated with neoplastic transformation of cells. Cells with induced, heritable phenotypic changes, such as morphological alterations, can be shown to have a higher propensity to progress to tumor cells, which validates the use of these phenotypic markers as quantitative measures of cell transformation. Cell transformation assays differ from other short-term in vitro assays for carcinogens because they are not predicated on a theoretical association between carcinogenesis and mutagenesis and therefore are able to detect chemical carcinogens that are not active in mutational assays. Cell transformation assays can be used for the identification of potential carcinogens, for studies of the mechanism of action of chemicals, and for studies of the carcinogenic process. Each of these uses are illustrated with the Syrian hamster embryo cell transformation model. This model uses normal, diploid cells and identifies a number of known human carcinogens not active in other short-term assays for carcinogens. The limitations of cell transformation assays are also discussed. One major limitation is the use of rodent cells rather than human cells, and the possible ramifications of this are discussed. The differences between transformation of human versus rodent cells have implications to the cancer and aging processes.

• 日本環境変異原学会の論文
• 1998-10-31

著者

• J.carl Barrett

  Laboratory Of Molecular Carcinogenesis National Institute Of Environmental Health Sciences National

• Barrett J.

  Laboratory Molecular Carcinogenesis National Institute Of Environmental Health Sciences National Ins

• Cynthia A.afshari

  Laboratory Of Molecular Carcinogenesis National Institute Of Environmental Health Sciences National

• Afshari Cynthia

  Laboratory Molecular Carcinogenesis National Institute Of Environmental Health Sciences National Ins

関連論文

• Ability of Fourteen Chemical Agents Used in Dental Practice to Induce Chromosome Aberrations in Syrian Hamster Embryo Cells
• INVOLVEMENT OF TELOMERE SHORTENING AND TELOMERASE IN CELL AGING AND IMMORTALIZATION
• 第26回大会シンポジウム 癌原性物質検出系としてのセルトランスフォ-メ-ション試験の現状

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