ピリダベンの毒性試験の概要

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The safety of pyridaben for users and consumers can be summarized as follows. The acute studies with technical material showed pyridaben to have moderate to low toxicity. Pyridaben caused no irritation of skin and eye and no contact sensitization. Pyridaben did not show mutagenic potential, was not oncogenic in rats and mice, did not affect reproductive performance in rats and was not teratogenic in rats and rabbits although decreases in bodyweight and food consumption were seen in teratology studies. In addition, the main effects seen in subchronic to chronic toxicity studies were the reduction of body-weight gain, depression of food consumption and impairment of food conversion efficiency. A specific target organ, however, was not identified. The NOEL's for chronic studies in rats, mice and dogs on a mg/kg bodyweight basis were comparable. The minimum value of the maximum no-effect level was 8 ppm in the oncogenicity study of mice. In conclusion, there were no adverse toxicological findings based on the above studies. Sanmite^[○!R] WP and Sanmite^[○!R] SC containing 20% pyridaben were registered by Japanese MAFF in 1991 as an acaricide and insecticide for various fruits as well as for tea. Pyridaben and its formulations were specified by Japanese MHW as harmful substances because of the acute toxicity data. However, the products are not considered to be a cause for concern in the safety of users and consumers provided they are used carefully and in accordance with the established standard for safe use.
日本農薬学会の論文
1994-11-20

ピリダベンの毒性試験の概要

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