The rapid screening of photogenotoxic compounds using photo plasmid-relaxation assay
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概要
- 論文の詳細を見る
To develop a simple and rapid screening system for detection of photogenotoxic chemicals, we applied the plasmid-relaxation assay to the in vitro photochemical genotoxicity assay system. Using 54 chemicals as model compounds, including known phototoxic and non-phototoxic chemicals, we evaluated the performance of the plasmid-relaxation assay. The results obtained here were comparable with published data that were assessed from in vivo phototoxicity systems. We concluded that the plasmid-relaxation assay is useful as a primary screening method to detect chemicals with photochemical genotoxicity.
- 日本環境変異原学会の論文
- 2001-10-20
著者
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Tanaka Noriho
Cell Toxicology Hatano Research Institute Food And Drug Safety Center
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Nakagawa Yuzuki
Cell Toxicology Hatano Research Institute Food And Drug Safety Center
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Takigawa Yuko
Cell Toxicology, Hatano Research Institute, Food and Drug Safety Center
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Takigawa Yuko
Cell Toxicology Hatano Research Institute Food And Drug Safety Center
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Tanaka Noriko
Cell Toxicology, Hatano Research Institute, Food and Drug Safety Center