Photochemical genotoxicity testing : experience with the Ames test and the in vitro chromosomal aberration assay

概要

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Photochemical genotoxicity can be detected using appropriately adapted versions of the bacterial mutagenicty test and the in vitro chromosomal aberration assay. For screening programmes it has been debated whether a photo-clastogenicity assay will be sufficient or whether the photo-Ames test will be necessary for complementation. In order to facilitate this discussion, we present data from in house investigations and refer to pertinent literature data showing that there is no clear precedent of a photochemical genotoxin which is exclusively positive in the bacterial assay. Furthermore, many of the photogenotoxins show only weak activity in the bacterial assay but are potently genotoxic in the clastogenicity assay. On the other hand, it might be prudent to include the bacterial assay because at present there is still a rather limited experience in photochemical mutagenesis testing.
日本環境変異原学会の論文
2001-10-20