ダイオキシンの生体作用の分子機構 : シンポジウム : II. ダイオキシンの生体影響

概要

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TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a prototype halogenated aromatic hydrocarbon, and it is considered to be one of the most potent toxicants ever studied. The adverse biological effects of TCDD seen in experimental animals include immune, reproductive, and developmental toxicity, carcinogenicity, wasting syndrome, chloracne, and lethality. In order to clarify the immunotoxicity of TCDD, we developed a cell culture system derived from human T cell leuke-mia, that provides unique advantages for studying the toxic responses and the molecular mecha-nisms underlying the action of TCDD. We proposed a hypothetical model to explain the multi-;* aspects of toxicity of TCDD. A Iigand-independent Ah receptor-activation pathway may play an important role in some developmental stages. Therefore, exogenous ligands for Ah receptor such as TCDD may mimic the physiological signal transductions. The toxicity of TCDD may be caused by indacing abnormal signaling.
日本環境変異原学会の論文
1999-07-12