Effect of hyperthermia on the micronucleus induction in mice

概要

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We investigated the time course of micronucleus induction by hyperthermia in the mouse to speculate on the possible mechanism. The hyperthermia was induced by ambient heat(37℃ for 4h). Statistically significant increases in micronucleated polychromatic erythrocyte frequencies were observed from 9h to 48h after the start of the hyperthermic treatment. The ratio of polychromatic erythrocytes to total erythrocytes remained almost constant. We also examined whether repeated hyperthermic treatment(37℃ for 3h)for 4 days can induce adaptation to micronucleus induction in mice. Statistically significant increases in micronucleated reticulocyte frequencies were observed from day 3 to day 6, the frequencies for those 4 days were not, which tended to decrease slightly, significantly different from each other. The results suggest that heat effect is not likely due to erythropoietic stimulation but might be due to disturbance of the mitotic apparatus, and repeated hyperthermia did not induce adaptation to micronucleus induction in mice.
日本環境変異原学会の論文
1998-07-21