Effect of Starvation on the Pancreatic A-cell and B-cell Functions in Rats
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概要
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There has been no study in ngard to the precise effect of starvation on the pancreatic A-cell and B-cell functions. To elucidate this issue, the secretion of insulin and glucagon in vivo [glucose (0.5 g/kg), arginine (0.5 g/kg), epinephrine (10 µg/kg) and insulin (0.6 U/ kg) infusion test] and in perfused pancreas was investigated in 6 rats starved for 48 h and 6 rats after overnight fast served as controls, respectively. In the glucose infusion test, the increment in insulin and the decrement in glucagon were significantly (P < 0.01 and P < 0.05) lower in 48 h fasted rats (67.3 ± 6.6 µU/mL and 3.5 ± 5.8 pg/mL, mean ± SEM) than in controls (121.7 ± 10.3 µU/mL and 21.0 ± 3.3 pg/mL), respectively, and the increment in blood glucose was significantly (P < 0.05) greater in 48 h fasted rats (235.7 ± 9.9 mg/dL) than in controls (189.8 ± 13.1 mg/dL). In arginine and epinephrine infusion tests, insulin and glucagon responses were not significantly different between 48 h fasted rats and controls. In the insulin infusion test, the increment in glucagon response to hypoglycemia was signifircantly (P < 0.001) Iower in 48 h fasted rats (99.5 ± 10.3 pg/mL) than in controls (243.2 ± 24.0 pg/mL). In perfused pancreas, insulin response to 16.7 mM glucose and glucagon response to 1.7 mM glucose were significantly lower in 48 h fasted rats, while glucagon response to epinephrine (200 pg/ mL) and both insulin and glucagon responses to 20 mM arginine in the presence of 5.6 mM glucose were almost the same in the 2 groups. These results indicate that starvation induces glucose insensitivity of the pancreatic A-cell as well as that of the pancreatic B-cell, which leads to glucose intolerance.
- 鳥取大学の論文
- 1995-03-01