Induction of Catalase Gene Expression in Hepatoma and Fibroblast Cell Lines with Peroxisome Proliferator (Clofibric Acid)

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概要

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• Peroxisome proliferators, which have been clinically used as hypolipidemic drugs, activate fatty acid β-oxidation enzymes in peroxisomes. Catalase, which decomposes hydrogen peroxide to water and oxygen, is one of peroxisomal enzymes. In this study, transcription of the catalase gene was shown to be slightly stimulated in hepatomas and fibroblast cell lines treated with clofibrate, as well as in the liver of the drug-administered animal. Furthermore, stimulation of the gene was also observed in the skin and brain tissues of the animal. Chloramphenicol acetyltransferase assays revealed that the catalase gene was regulated positively and negatively by clofibrate in the fibroblast, and that the peroxisome proliferator-responsive element (PPRE) located at -3957 base pair (bp) in the catalase gene served as positive regulator element of the transcription, meanwhile PPREs at -3151 bp and -301 bp negatively modulated the gene.

• 鳥取大学の論文

著者

• Nakamura Emi

  Department of Biology, Faculty of Education, Mie University

• Nakamura Emi

  Department Of Biology Faculty Of Education Mie University

• Nakamura Emi

  Department Of Molecular Biology Faculty Of Medicine Tottori University

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• Induction of Catalase Gene Expression in Hepatoma and Fibroblast Cell Lines with Peroxisome Proliferator (Clofibric Acid)

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