Kinetics of the Levels of Pro- and Anti-Inflammatory Cytokines and Vascular Endothelial Growth Factor in Serum and Pleural Fluid after Major Lung Resection for Lung Cancer
スポンサーリンク
概要
- 論文の詳細を見る
Some pro- and anti-inflammatory cytokines and angiogenesis-related factors play important roles in the inflammatory response after surgery. To study their kinetics and mutual relationships after major lung resection for lung cancer, concentrations of interleukin (IL)-6, -8 and -10 and vascular endothelial growth factor (VEGF) were measured in serum and pleural fluid. Venous blood and pleural fluid samples were collected before and up until 5 days after surgery from 10 patients with lung cancer, treated by standard lobectomy at Tottori University Hospital between 1997 and 1999. Cytokine levels after surgery were significantly higher than control levels before surgery in serum and pleural fluid. In pleural fluid, cytokines and VEGF increased after surgery 10 to 100 times than in serum. IL-6 and -10 reached their peaks in pleural fluid later than in serum, and then gradually decreased. Serum IL-8 reached its peak at 3 h, decreased until day 2 and then remained stable. Serum VEGF decreased until 3 h, and then showed little change. Pleural fluid IL-8 and VEGF reached their peaks at 3 or 6 h, decreased until day 2 and then increased up to day 5. The amount of cytokines produced per hour in drainage pleural fluid showed nearly the same kinetics as serum cytokines. Serum cytokines and VEGF showed higher coefficient values to the hourly production in pleural fluid than to the pleural fluid levels. During wound healing, IL-8 acted as a pro-inflammatory cytokine in the early phase, but as an angiogenic factor like VEGF in the late proliferative phase. The cytokine production per hour in pleural fluid is believed to be a useful marker of cytokine levels for evaluating surgical trauma after major lung resection for lung cancer.
- 鳥取大学の論文
著者
-
Taniguchi Yuji
Division Of General Thoracic Surgery Tottori University Hospital
-
Taniguchi Y
Tottori Univ. Fac. Medicine Yonago Jpn
関連論文
- Pleomorphic Carcinoma of the Lung in Which the Sarcomatous Element Grew Rapidly : A Case Report
- Thoracoscopic Extended Thymothymectomy for Myasthenia Gravis with Aplastic Anemia
- Lymphatic vessel density in pulmonary adenocarcinoma immunohistochemically evaluated with anti-podoplanin or anti-D2-40 antibody is correlated with lymphatic invasion or lymph node metastases
- Laparoscopic Bilateral Partial Adrenalectomy for Adrenocortical Adenomas Causing Cushing's Syndrome : Report of a Case
- Primary Adenocarcinoma of the Trachea Resected Using Percutaneous Cardiopulmonary Support (PCPS)
- Spontaneous Regression of Lung Adenocarcinoma : Report of a Case
- Pulmonary mucinous cystadenoma : a rare benign tumor of the lung
- Surgical outcome of video-assisted thoracic surgery for acute thoracic empyema using pulsed lavage irrigation
- Subpleural Intrapulmonary Lymph Node Metastasis from Colorectal Cancer
- Mediastinal lymph node carcinoma of an unknown primary site : clinicopathological examination
- Video-assisted thoracic surgery for left lung cancer in a patient with a right aortic arch
- Smoking Affects Prognosis After Lung Cancer Surgery
- Pulmonary lymphangioleiomyomatosis with concomitant tuberous sclerosis complex diagnosed by video-assisted thoracoscopic surgery
- Pulmonary Arteriovenous Fistula with Cerebral Infarction Successfully Treated By Video-Assisted Thoracic Surgery
- Thoracoscopic Resection of Middle Mediastinal Noninvasive Thymoma : Report of a Case
- Successful Video-Assisted Thoracic Surgery for Pulmonary Endometriosis : Report of a Case
- CD1a expression in PEComas
- Benign clear (sugar) cell tumor of the lung with CD1a expression
- Kinetics of the Levels of Pro- and Anti-Inflammatory Cytokines and Vascular Endothelial Growth Factor in Serum and Pleural Fluid after Major Lung Resection for Lung Cancer
- Sister Mary Joseph's nodule that originated from lung adenocarcinoma
- Thoracoscopic resection of a thoracic duct cyst that developed during follow-up for a thymic cyst
- Radiation-Induced Synovial Sarcoma of the Lung Diagnosed by Gene Analysis after the Surgical Resection of Chondrosarcoma Arising from the Scapula
- A Successful Case of Robotic Bronchoplastic Lobectomy for Lung Cancer
- First experience of robotic extended thymectomy in Japan for myasthenia gravis with thymoma
- Thoracoscopic resection with intraoperative use of methylene blue to localize mediastinal parathyroid adenomas