催奇形性における薬剤評価の検索率と関連性

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Since March 1995, counseling pregnant women about possible drug effects was started at the clinical Department of Obstetrics and Gynecology, in Niigata University Hospital, assisted by pharmacists. Regarding the counseling a pregnant women or women who have a high chance of becoming pregnant, information regarding the risk of congenital anomalies for various medicines and the choice of the literature information are the most important types of nformation. In order to provide information in the past, we examined reference manuals for available information on congenital abnormalities according to each category or medicine, and the compatibility of the respective information. We next analyzed the validity or the manuals depending on the drug information. We studied 625 drugs under their commercial names as requested by clinicians. Our findings show, as noted in parenthesis below, the results of 291 drugs under their product name. We examined 4 manual, and rated the drugs in each manual as follows: "Drugs in Pregnancy and Lactation (DPL)" Risk factors: A, B, C, D and X "Physicians' Disk Reference (PDR)" FDA-defined pregnancy risk factors: A, B, C, D and X "Prescribing medicines in pregnancy by The Australian Drug Evaluation Committee (ADEC)" The Australian categorization: A, C, B1, B2, B3, D and X "Drugs in Pregnancy: Toranomon Hospital (TORANOMON)" Drug evaluation: 0-5 points In each manual, we found drug information under commercial names and product name in 32.3-49.6% and 30.9-41.6%, respectively, and if we searched three manuals, finding the commercial names and product name increased to 57.4-71.1% and 50.9-62.5% respectively. Our findings suggested that a combination of the available literature, using at least 3 reference manuals, was an efficient method for obtaining information on congenital anomalies.
日本医療薬学会の論文
2003-04-10

催奇形性における薬剤評価の検索率と関連性

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