臭化ジスチグミンの血清コリンエステラーゼ値への影響 : 直腸癌患者に対して

概要

論文の詳細を見る
The main pharmacological action of distigmine bromide is to bind with choline esterase to inactivate it and increase the activity of acetylcholine. However, few studies have previously described the extent of distigmine bromide's effect on the living body. In this study, the effect of distigmine bromide on serum choline esterase was examined in 119 patients with rectal cancer. Neurogenic bladder developed in 40.3% of the patients who received surgery for rectal cancer, and 50.3% of them were treated with distigmine bromide. Although this treatment reduced the serum choline esterase levels by 30.1%, on average, the rate of reduction varied among the patients. When comparing the rate of reduction of choline esterase in patients aged 65years of age or older with those less than 65years of age, the rate was found to be higher in the older group. Diarrhea, which is one of the effects of excess distigmine bromide, was observed in 33. 3%, and the rate of reduction for serum choline esterase was higher in those with diarrhea. Distigmine bromide should be carefully administered. particularly in old patients, whiie closely monitoring the serum choline esterase levels and the occurrence of possible digestive symptoms. Such observations are also important for preventing a cholinergic crisis.
日本医療薬学会の論文
2001-10-10