匂い情報の細胞内変換過程(<特集>「匂い」情報処理研究の新展開)

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概要

• 論文の詳細を見る

• The perception of odors begins with depolarization of the olfactory receptor cells. This transduction process is mediated by G-protein-linked activation of adenylate cyclase, which produces a membrane current by direct gating of cationic channels (cAMP-gated channels) located in ciliary plasma membrane. Opening of these cAMP-gated channels allows monovalent as well as divalent cations to enter the ciliary cytoplasm, and this Ca^<2+> influx serves two important functions. First, the Ca^<2+> influx activates a Cl^- current, which stabilizes the transduction current during fluctuations in extracellular cation concentration and increases the total current activated by cAMP. Second, the Ca^<2+> influx mediates adaptation by providing negative feedback at several stages in the transduction mechanism.

• 日本生物物理学会の論文
• 1994-03-25

著者

• 倉橋 隆

  ペンシルバニア大学モネル化学感覚研究所

• Gold Geoffrey

  ペンシルバニア大学モネル化学感覚研究所

関連論文

• 嗅細胞における情報変換機構とモジュレーション
• 匂い情報の細胞内変換過程(<特集>「匂い」情報処理研究の新展開)

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