白血球のスーパーオキシド生成機構について
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概要
- 論文の詳細を見る
The generation of superoxide and oxygen-derived free radicals by the phagocytes (neutrophils, monocytes and macrophages) is catalyzed by a membrane-bound NADPH oxidase system which is dormant in resting cells and becomes activated during phagocytosis or by stimulating cells with suitable soluble stimulants. This oxidase system has been thought to be an electron-transport chain consisting of a flavoprotein, a b-type cytochrome (cytochrome b-558 : cyt b-558) and cytosolic components (p47-phox, p67-phox and unknown factor). When activated, these components seem to act synergistically to form superoxide, but the roles of these components in the electron transport system are not fully elucidated.
- 日本生物物理学会の論文
- 1991-11-25