骨格筋の興奮 : 収縮連関と膜内電荷移動

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概要

• 論文の詳細を見る

• Intramembrane charge movement (IMCM) in skeletal muscle cells has been proposed to underlie the process leading to Ca^<2+> release from the sarco-plasmic reticurum. The dihydropy-ridine (DHP) receptor in transverse-tublar membrane is suggested to be responsible for the excitation-contraction coupling (E-C coupling). The skeletal muscle cells in dysgenic mice are characterized by a dramatic reduction of DHP receptor and absence of E-C coupling. We have recorded IMCM in skeletal muscle cells from normal and dysgenic mouse fetuses. The amount of maximum charge in mutant muscle was less than 30% of that in normal muscle. Nifedipine, a DHP derivative, reduced the amount of charge in normal muscle by 40%, but did not in the dysgenic muscle. The results suggest that the DHP sensitive component is essetial if IMCM plays a key role in the signal-transduction mechanism underlying E-C coupling.

• 1991-07-25

著者

• 島原 武

  Cnrs フランス

• Bournaud Roland

  パリ大xii校 フランス

• 井上 勲

  徳島大学酵素科学研究センター

• 島原 武

  CNRS, フランス

関連論文

• 骨格筋の興奮 : 収縮連関と膜内電荷移動

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