ホモポリペプチド鎖のβ構造形成の速度論
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概要
- 論文の詳細を見る
Current status of the study on the kinetics of β -sheet formation of homopolypeptides is reviewed. A reasonable estimate is presented of the folding time of polypeptide chains into the β -sheet, which is much shorter than the time required for the folding of many globular proteins. The folding rate increases with the stability of the β -sheets as found from the effects of pH, temperature, and denaturants. A simple model is introduced to account for strong dependence of the folding rate on the linear charge density of polypeptide chains. Finkelstein's model is briefly discussed in this context.
- 日本生物物理学会の論文
- 1990-07-25