10. BMP4 induce ectopic cartilage formation in the mouse embryonal mandibular process : BMP4 mediates Msx2 and Sox9 expression during chondrogenesis.
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概要
- 論文の詳細を見る
To examine the fuunction of BMP4 on chondrogenesis in the mandibular process, we implanted hrBMP4-soaked beads and micro-injected Msx2 gene carrying Adenovirus (AdV-Msx2) into E1O mouse mandibular organ culture explants. BMP4-soaked beads induced ectopic cartilage at posterior portion of the explant but not at the anterior portion. BMP4 induced Msx2 and Sox9 expression simultaneously but the expression levels were very high at the anterior portion. Furthermore AdV-Msx2 micro-injection in the explant showed focal inhibition of Meckel's cartilage formation and Col2a1 expression. The findings suggest that BMP4 mediates expression of antagonistic functional transcriptional factors of Msx2 and Sox9 on the chondrogenesis.
- 硬組織再生生物学会の論文
- 1998-10-04
著者
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Slavkin C
National Institute Of Dental Research Nih
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Nonaka Kazuaki
Department Of Pedodontics Faculty Of Dentistry Kyushu University:craniofacial Development Section Ni
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Semba Ichiro
Department Of Computer Science Ibaraki University
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Takahashi Katsu
Craniofacial Development Section, NIAMS, NIH
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Shum lilian
Craniofacial Development Section, NIAMS, NIH
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Shum Lilian
Craniofacial Development Section Niams Nih
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Takahashi Katsu
Craniofacial Development Section Niams Nih
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Semba Ichiro
Department Of Oral Pathology Kagoshima University Dental School:craniofacial Development Section Nia
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Nonaka Kazuaki
Department of Pediatric Dentistry, Graduate School of Dental Science, Kyushu University
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Nonaka Kazuaki
Department of Pediatric Dentistry, Division of Oral Health, Growth and Development, Kyushu University
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