Skeletal Defects and Pyridinium Crosslinks in Copper-Deficient Foals

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概要

• 論文の詳細を見る

• The effect of dietary copper-deficiency was tested in growing horses. After two months on the experimental diet, the horses started to develop abnormalities in their limbs. Quantitation of pyridinoline, a 3-hydroxypyridinium crosslink, showed much lower valuesin the femoral tissues of five low-copper foals which developed cartilage lesions and microfractures in the bone. Samples from the control and three low-copper foals without any defects showed similar normal values. Metalloproteinases secreted from explants of articular cartilage was significantly elevated only in the affected foals suggesting that these changes are probably a secondary tissue response to the damage.

• 硬組織再生生物学会の論文
• 1994-10-29

著者

• Choi James

  Laboratory For The Study Of Skeletal Disorders And Rehabilitation Harvard Medical School And The Chi

• Mikuni-takagaki Yuko

  Laboratory For The Study Of Skeletal Disorders And Rehabilitation Harvard Medical School And The Chi

• Hurtig Mark

  Department of Clinical Studies, Ontario Veterinary College, University of Guelph

• Hurtig Mark

  Department Of Clinical Studies Ontario Veterinary College University Of Guelph

関連論文

• Skeletal Defects and Pyridinium Crosslinks in Copper-Deficient Foals

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