Morphological Investigation of Cultured Human Dental Pulp Cells

概要

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Light and electron-microscopic investigations on cultured human dental pulp cells were carried out. Cells in the third culture were revealed to have an rather fibroblastic appearance under inverted phase contrast light microscopy, and formed alizarin red S positive nodular structures in the culture matrices. Odontoblast-like cytodifferentiation occurred in the cultured pulp cells having eccentrically located nuclei and well-developed intracytoplasmic organella as seen on electronmicroscopic observations. These phenomena were independent of the influence of dentine particles and of 1α, 25-dehydroxyvitamin D 3 having been supplemented in the culture media. The present data Indicate that the human dental pulp essentially contains a cell lineage which could be differentiated to cells capable of mineralization.
硬組織再生生物学会の論文
1994-03-25