躁うつ病の日内リズムについて : 特に血清セトロニンの日内変動(各科におけるうつ病)

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The present study dealt with circadian variation of serum 5HT levels and the change of those during sleep deprivation and after a loading dose of L-5HTP in manic-depressed illness. 1. Circadian variation of serum 5HT level was measured at 8,12,20 and 24 o'clock in 12 normal subjects, 4 manic and 6 depressed patients respectively. There was no significantcircadian variation in each group. 2. The changes of serum 5HT level during sleep deprivation were determined in 9 normal subjects and 8 depressed patients (4 patients who received no psychotropic drug and 4 patients who received tricyclic antidepressants) at 20 and 24 o'clock of the first day of sleep deprivation and at 4,8,12 and 20 o'clock of the following day. There was no significant change in normal subjects. On the contrary, the serum 5HT level during sleep deprivation in the depressed group, who received no drug-treatment, showed a tendency increase This was especially, the case in the serum 5HT levels at 8 and 12 o'clock of the first day. 3. serum 5HT level after single administration of L-5HTP was investigated in 6 normal, 4 manic and 6 depressed patients. As a loading dose, L-5HTP 3mg/kg was given orally to all subjects at 8 o'clock in the morning. Serum 5HT level was examined at 8,9,10,12,16,20 and 8 o'clock of the next day. The results were rether scatter, but serum 5HT level for depressed patients showed a tendency to decrease, one and two hours after administration of L-5HTP. On the contrary, those in manic patients showed a tendency to increase one and two hours after the loading. those in normal subjects showed a tendency to increase 12 hours after the loading. 4. It seems that the sleep deprivation influenced the 5HT metabolism in depressed patients. The response to L-5HTP loading was different between manic and depressed groups, indicating a different activity of decarboxylase between manic and depressed groups, indicating a different activity of decarboxylase between them.
日本心身医学会の論文
1978-02-01

躁うつ病の日内リズムについて : 特に血清セトロニンの日内変動(各科におけるうつ病)

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