NCA患者における呼吸の不規則性ならびにそれに及ぼすβ遮断剤およびMinor tranquilizerの影響
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概要
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Sighing respiration or shortness of breath has been reported as a frequent characteristic sign of patients with neurocirculatory asthenia (NCA). Practically ventilatory capacities of such patients were normal, but tidal volumes at rest were quite irregular on spirometoric observation.In this study, the degree of respiratory irregularity was measured by means of standard deviation of the tidal volume. And changes of respiratory irregularity, pulse rate, respiratory resistance, %FEV_<1・0>, %vital capacity and subjective symptome by intravenous injection of beta-adrenergic blockade (propranolol) were investigated in 21 cases with NCA.After the administration of propranolol, 9 (Group A) of 21 NCA cases showed significant decrease of respiratory irregularity, pulse rate and %FEV_<1・0>. Respiratory resistance slightly decreased ; %vital capacity did not change ; and subjective symptome improved in 67% of them.On the other hand, in another 12 cases (Group B) respiratory irregularity, %FEV_<1・0> and %vital capacity showed no significant change, and subjective symptom improved in 33%. Pulse rate decreased, but degree of the decrement was less than Group A.It was considered that patients with NCA would be classified into two groups, that is, Group A and Group B, and patients of Group A who are sensitive to beta-adrenergic blockade have a irritable betaadrenergic receptor. On the other hand it was suggested that patients of Group B who are not so sensitive to beta-adrenergic blockade and significantly sensitive to minor tranquilizer (oxazolam) should have a psychogenic factor which plays an important role in their complaints.
- 日本心身医学会の論文
- 1971-10-01