サーカディアン・リズムの同調機序とその異常(生体リズムと心身症第30回日本心身医学会総会)

概要

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Various types of circadian rhythm disorders have been so far reported in human subjects. Almost all of them are due to disordered entrainment of the circadian rhythms of behaviors and physiological functions. Entrainment to socio-environment cycles and/or entrainment between various circadian rhythms in the same individual are impaired. The etiology of the circadian rhythm disorders is divided into two categories : 1) interactions between socioenvironmental cycles and circadian system which induce the disorders even in normal subjects, e.g., desynchronosis induced by jet lag or work-shift, self-imposed irregular schedules, and photoperiodic disorders of circadian rhythm;and 2) intrinsic defects in circadian system which induce the disorders even on normal socio-environmental cycles, e.g., non-24-hour sleep-wake syndrome, delayed or advanced sleep phase syndrome, and endogenous depression. Zeitgebers, which include bright light, social time cues and sleep-wake schedule, can be used for the treatment of the entrainment disorders, where the strength and timing of zeitgebers imposed are crucial. Some drugs (e.g., lithium and clomipramine) which can alter the intrinsic period of circadian rhythm, are used for correcting abnormally delayed or advanced phase of circadian rhythm. Insight based on circadian principles is important to understand the etiology of circadian rhythm disorders and to develop their treatments..
日本心身医学会の論文
1990-04-01