IL-12/IL-18のマウス扁平上皮癌に対する抗腫瘍効果の検討

概要

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Interleukin-12 (IL-12) and interleukin-18 (IL-18) exhibit strong anti-tumor effects, and induce cytokines with many similarities in function, such as induction of IFN- γ production. Concomitant administration of IL-12 and IL-18 may increase the effects. In this study, we used squamous cell carcinoma that spontaneously developed in inbred strain WHT/Ht mice. IL-12 and IL-18 were administered alone or concomitantly to tumor-bearing mice, and the antitumor effects of the cytokines were compared. As a result, the tumor growth was inhibited by IL-12 and IL-18, and prolonged survival. IFN- γ production was also increased. On measurement of cytotoxic activity and NK activity, administration of IL-12 and IL-18 increased the activities. All these effects were stronger in the concomitant administration group than the single administration groups, but body weight decreased in the concomitant administration group. The above findings suggested that the antitumor effects of IL-12 and IL-18 are exerted via T cells and NK cells, which increase IFN- γ production and enhance cellular immunity.
岩手医科大学歯学会の論文
2002-04-26