Endostatinのマウス扁平上皮癌に対する抗腫瘍効果に関する研究

概要

論文の詳細を見る
Endostatin, a fragment of collagen XVIII, is a potent antitumor protein, but the mechanism of its action is not yet clear. There is little report concerning antitumor action of endostatin on squamous cell carcinoma occurring in the head and neck. This study examined the antitumor effect and anti-angiogenesis effect of endostatin on murine squamous cell carcinoma, and the effect on the cell proliferation and tube formation of normal human umbilical vein endothelial cell (HUVEC). As a result, endostatin induced reduction of murine squamous cell carcinoma growth and that of tumor angiogenesis. Moreover, endostatin inhibited cell growth and tube formation for HUVEC. In this time, the ratio of S-phase cells was decreased by endostatin-treatment. These findings suggested that the antitumor effect of endostatin was caused through the inhibition of angiogenesis, which was induced by the decreasing of S-phase endothelial cells.
岩手医科大学歯学会の論文
2004-04-26