マウス扁平上皮癌の増殖に対するiNOS阻害薬の影響

概要

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Angiogenesis is associated with tumor growth and metastasis in patients with solid tumors, including those of the head and neck. Nitric oxide (NO) production may contribute to these processes. NO production in the tumor depends on the iNOS. 1400W is the most selective iNOS inhibitor and strongly prevents NO production by the iNOS. In the present study, the effect of 1400W on tumor-induced angiogenesis and tumor proliferation was examined using a weakly immunogenic squamous cell carcinoma of the WHT/Ht mouse. 1400W inhibited the angiogenesis induced by the murine tumor dose-dependently, and the number of blood vessels orientated towards the intradermal tumor was maximally reduced by 62.5% compared to the control. In the tumor proliferation assay, 1400W significantly inhibited proliferation of the subcutaneously inoculated tumor, and reduced the tumor volume by 60.0% (20mg/kg) and 75.7% (lOmg/kg) compared to the control. Subcutaneously inoculated tumors were observed by the Immunohistochemistry and Western blot analysis, and iNOS and VEGF expression was lowered with administration of 1400W compared to the control. These results suggest that 1400W has significant inhibitory activities against in vivo tumor-induced angiogenesis and proliferation of murine squamous cell carcinoma.
岩手医科大学歯学会の論文
2004-04-26