心筋虚血における収縮機能異常の先行 : 無麻酔覚醒犬による拡張機能異常との経時的対比
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概要
- 論文の詳細を見る
Initial effects of global left ventricular (LV) ischemia induced by left main coronary artery occlusion (CAO) on indexes of systolic and diastolic LV function in conscious dogs were studied to determine whether diastolic abnormalities precede systolic dysfunction or vice versa during the onset of global ischemia. Indexes of systolic function (e.g., peak positive first derivative of LV pressure, ejection fraction, and velocity of circumferential endocardial fiber shortening) were also depressed significantly before (by 5-15 beats) indexes of LV diastolic function [e.g., time constant of isovolumic relaxation and LV myocardial and chamber stiffness (by 35-45 beats)]. Similar results were observed in the presence of autonomic blockade, when heart rate did not change with CAO. Thus, during the induction of acute global LV ischemia in conscious dogs, LV systo1ic dysfunction occurs before diastolic dysfunction.
- 鈴鹿医療科学大学の論文
- 1995-03-31