長期容量負荷による血管の再構築に対するCV-11974の効果
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Long-term volume overload causes an enlargement of vessels. This study was undertaken to examine the effects of angiotensin II type 1 (AT-1) receptor antagonist CV-11974 on the flow-induced vascular remodeling. Our methods involued the use of an artcvia-venous shunt made between the left common carotid artery and the external jugular vein in 17 rabbits. Six weeks after the shunt formation, rabbits were randomly assigned to 2 groups: CV-11974 (CV) and saline groups. Two groups were administered CV or saline for 6 weeks. Sham-operated rabbits were given saline and used as control. The results showed a relationship between the cube of luminal diameter and flow was linear in CV and saline groups, and this relationship was steeper in CV than in saline group. In isolated carotid arteries, isometric tension produced by angiotensin II was significantly augmented at the shunt side in saline group, and this was attenuated to 8% and 7%, respectively, after CV in arteries of shunt and contralateral sites. Derangement of acetylcholine-induced endothelium dependent relaxation was noted at the shunt side as compared with the contralateral vessels, which was partially reverted to the level of sham by CV administration, our conclusions were that vascular remodeling, hypercontractile response to angiotensin II and reduced endothelium-dependent relaxation in chronic volume overload vessels were improved following a long-term administration of AT-1 antagonist. Key words : shunt, angiotensin, endothelium-derived factors, remodeling
- 山形大学の論文
- 2004-02-16
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- 長期容量負荷による血管の再構築に対するCV-11974の効果