LONG-TERM ADMINISTRATION OF ATORVASTATIN, AN HMG-COA REDUCTASE INHIBITOR, HAS BENEFICIAL EFFECTS ON KIDNEYS IN AUTOIMMUNE DISEASE MICE MODEL

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概要

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• The fact that 3-hydro-3-methylglutaryl coenzyme A reductase inhibitor (statin) can also functions as an immunosuppressive agent has recently gained wide recognition. However, it is not clear whether these drugs are effective in long-term treatment of chronic kidney disease. I investigated the effect of an atorvastatin long-term administration using histological methods and an autoimmune disease mouse model. Glomerular matrix expansion in the group administered 0.5 mg/kg atorvastatin was suppressed compared to the vehicle-treated group. IgG 3 deposition in loop lesions of both in atorvastatin-treated groups was less than in the vehicle-treated group of mice. Proliferating cell infiltration in glomeruli of the atorvastatin-treated groups was also less than in the vehicle-treated group of mice. These results suggest that atorvastatin has beneficial effects on kidney damage in an autoimmune disease mice model when administered long-term at an appropriate dose.

• 名古屋市立大学の論文
• 2003-02-28

著者

• 伊藤 彰典

  名古屋市立大学第三内科

• 伊藤 彰典

  名古屋市立大学大学院医学研究科

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• LONG-TERM ADMINISTRATION OF ATORVASTATIN, AN HMG-COA REDUCTASE INHIBITOR, HAS BENEFICIAL EFFECTS ON KIDNEYS IN AUTOIMMUNE DISEASE MICE MODEL

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