Insulin as the "Primary" Autoantigen in Type 1 Diabetes?

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概要

• 論文の詳細を見る

• Type 1 diabetes of both the human and NOD mouse is associated with autoimmunity directed against insulin which is the only β cell specific autoantigen. Variable number of tandem repaats in the 5' region of insulin gene on chromosome 11 is associated with the risk of type 1 diabetes in human. Mice have two insulin genes including the insulin 1 gene(chromsome 19)and the insulin 2 gene(chromsome 7). The insulin 2 gene knockout when bred onto NOD mice accelerates diabetes. In contrast to insulin 2,diabetes and insulitis were markedly reduced in insulin 1 knockout mice with decreased and delayed diabetes. Autoantibodies to insulin can predict diabetes in man and NOD mice. Insulin peptides can be used to induce insulitis and diabetes in non-diabetic strain mice. Our results suggest that insulin molecule is a possiible primary autoantigen that intiates a pathogenesis of type 1 diabetes. An administration of insulin or its peptide can prevent the development of diabetes in NOD mice but we cannot at present safely prevent type 1 diabetes in humans. A series of clinical trials are under way and planned.

• 長崎大学の論文

著者

• Abiru Norio

  The First Department Of Internal Medicine Nagasaki University School Of Medicine.

関連論文

• Insulin as the "Primary" Autoantigen in Type 1 Diabetes?

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