<原著>喫煙の気管支肺胞洗浄液 (BALF) 細胞, 末梢血細胞に及ぼす影響に関する検討

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概要

• 論文の詳細を見る

• この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されました。It has been reported that smoking causes various pulmonary disorders including lung cancer, pulmonary emphysema and some interstitial lung diseases. To evaluate the influence of smoking on the human lung, we compared BALF cells findings of non-smokers, smokers and ex-smokers. The results are as follows : 1. A significant decrease of BALF recovery and an increase in the number of BALF cell in smokers were found compared to those in non-smokers. 2. Among the BALF cell populations, a significant increase of BALF macrophages were found in smokers compared to non-smokers. No such a difference could be found as to lymphocytes. 3. As to the subsets of BALF macrophages, a significant icrease of OKM1^+, OKM5^+ and OKT6^+ cells in smokers were found compared to those in non-smokers. 4. As to the subset of BALF lymphocytes, a significant increase of OKT8^+ cells and decrease of OKT4^+ cells in smokers resulted in a significant decrease of OKT4^+/OKT8^+ ratio. The above results contribute to an understanding of the mechanism of lung injuries attributable to smoking and also the understanding of the pathogenesis of tobacco-related lung diseases.

• 京都大学の論文
• 1987-08-31

著者

• 渡辺 和彦

  京都大学結核胸部疾患研究所内科学第二

• 渡辺 和彦

  京都大学結核胸部疾患研究所内科2

関連論文

• 7 喫煙の BALF 細胞, 細胞構成に及ぼす影響に関する検討(BAL (1))
• 喫煙の気管支肺胞洗浄液 (BALF) 細胞, 末梢血細胞に及ぼす影響に関する検討
• Analysis of BALF cell findings in the cases of pulmonary sarcoidosis with more than 5 years duration
• BALF cell findings and prognosis in pulmonary sarcoidosis:Studies on patients detected by health examination
• Effect of Angiotensin II on accessory function of BALF macrophage and blood monocyte in Sarcoidosis
• Effects of smoking in sareoidosis
• γ-IFN production of alveolar macrophages in sarcoidosis

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