<研究論文>ドーピング薬を反復投与した時のマウス自発運動量の変化

概要

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Morphine, cocaine, amphetamine, scopolamine or atropine at the dose of 10μmol/kg each, or saline was injected subcutaneously to mice once a day for 21 days, and spontaneous locomotor activity (SLMA) was measured immediately after injection for 2 hours on 1st, 7th, 14th and 21st day. Morphine, cocaine, amphetamine and scopolamine but not atropine increased SLMA significantly on 1st day. The degree of SLMA of mice received saline, atropine or scopolamine was gradually decreased with the passage of day, i.e., the level of SLMA on 21st was significantly lower than that on 1st day. In contrast, the magnitude of the increase in SLMA after amphetamine on 21st day was significantly higher than that on 1st day, i.e., the development of "reverse tolerance" to the effect of amphetamine was shown. However, the magnitude of the increase in SLMA produced by cocaine on 1st day was not significantly different from that on either 7th, 14th or 21st day. And the degree of the increase in SLMA induced by morphine on 7th day was lower than that on 1st day, but was gradually increased from 7th to 21st day, i.e., the level of SLMA on 21st day was recovered to that on 1st day. The results showed that "reverse tolerance" to the effect of amphetamine was developed fast but that of some substances seemed to be developed slow, and that of other substances was likely not to be developed.
東海大学の論文
1993-03-05