脊髄虚血に対する硬膜外冷却灌流を用いた脊髄保護の実験的検討

概要

論文の詳細を見る
Paraplegia remains a major devastating complication of operations on the descending thoracic aortic and the thoracoabdominal aortic aneurysm. The purpose of this study is to examine the effects of epidural cooling on spinal cord and systemic temperatures and to determine if selective spinal cord hypothermia is protective against ischemic injury which is mediated by two types of neural cell death, necrosis and apoptosis. Twenty-seven New Zealand White rabbits were used in this study and divided into three subgroups: a control group (n=3), a 40-minutes normothermic ischemia group (n=12), and a 40-minutes hypothermic ischemia with epidural cooling group (n=12). All hypothermic group animals exhibited full neurological recovery, whereas all normothermic group animals suffered from complete paraplegia. There were no histopathologic abnormalities in control and hypothermic groups. These results demonstrate that selective spinal cord hypothermia obtained by epidural cooling facilitates complete recovery of neurological functions and protection against ischemic injury which is mediated two types of neural death, necrosis and apoptosis.
札幌医科大学の論文
2002-08-01