高血圧の成因に関わるインスリン感受性におよぼす脂肪と遺伝の影響

概要

論文の詳細を見る
Insulin resistance is one of the most important factors in hypertension, which is along with obesity and body fat. This study was done to clarify the relationship between insulin resistance and body fat in terms of environmental influences, and to examine the relationship between insulin resistance and family history of hypertension. In the first study, body fat distribution was estimated by computed tomography and insulin sensitivity (M-value) was measured by the euglycemic hyperinsulinemic glucose clamp technique in 20 young male normotensives. There was a significant negative correlation between M-value and BMI in all subjects (r=-0.568, p<0.01), while there was no such correlation in non-obese subjects. And there was a significant negative correlation between M-value and intra-abdominal fat at L1 and L3 vertebral body levels in all subjects (L1 level: r=-0.691, p<0.01, L3 level: r=-0.706, p<0.01). Moreover there was also a significant negative correlation between them in 17 non-obese subjects (L1 level: r=-0.501, p<0.05, L3 level: r=-0.558, p<0.01). In the second study, a 75 g oral glucose tolerance test (75 g OGTT) and euglycemic hyperinsulinemic glucose clamp technique were performed in 6 young male normotensives with a family history of hypertension (FH (+)) and 8 without such a history (FH(-)). There were no significant differences in basal level of plasma glucose (PG), plasma immuno-reactive insulin (IRI) between FH (+) and FH(-). IRI tended to be higher in FH (+) than FH (-) at 120 minutes of 75 g OGTT. There was no significant difference between these two groups in PG or IRI at any time of 75 g OGTT, while FH (+) showed a significantly lower M-value than FH(-) (191.1±15.9 vs 254.7±16.2 mg/m2/min, p <0.05). These data suggest that intra-abdominal fat may contribute to the pathogenesis of hypertension through the reduction of insulin sensitivity not only in obese subjects but also in non-obese subjects, and that family history of hypertension reduces insulin sensitivity. Therefore, it is concluded that obesity and heredity together may play an important role in the pathogenesis of essential hypertension by reducing insulin sensitivity.
札幌医科大学の論文
1998-12-01

高血圧の成因に関わるインスリン感受性におよぼす脂肪と遺伝の影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク