A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis
スポンサーリンク
概要
- 論文の詳細を見る
A simple and reproducible screening method of macrofilaricides is described. The method evaluated in the present paper is based on inhibitory activity of the drugs on acid-phosphatase of Dirofilaria immitis adult worms. The potent inhibitor of acid-phosphates, NaF, inhibited completely the enzymic activity at 1 mM. trimelarsan, suramin and flubendazole inhibited partially the enzymic activity. Their inhibitory activity is comparable to that of Na_2HAsO_4, a specific inhibitor of phosphatase. Diethylcarbamazine and levamisole did not inhibit the phosphatase of D. immitis.
- 長崎大学の論文
著者
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Mitsui Yoshinori
Department Of Parasitology Institute Of Tropical Medicine Nagasaki University
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Jun Maki
Department Of Parasitology Kitasato University School Of Medicine Sagamihara 228-8555 Japan
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Masahiro KUWATA
Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, 228-8555 Japan
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Toshinori MITSUI
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, 852-8523 Japan
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Toshinori Mitsui
Department Of Parasitology Institute Of Tropical Medicine Nagasaki University 852-8523 Japan
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Masahiro Kuwata
Department Of Biochemistry Kitasato University School Of Medicine Sagamihara 228-8555 Japan
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Maki Jun
Department Of Anesthesiology St. Mary's Hospital
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Kuwata Masahiro
Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, 228-8555 Japan
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