EFFECT OF ROXITHROMYCIN ON PHAGOCYTOSIS-CONNECTED OXYGEN CONSUMPTION AND OPSONIZING ACTIVITY IN WHOLE BLOOD

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概要

• 論文の詳細を見る

• The modulation of host antimicrobial activity by antibiotics is of therapeutic importance. The effect of serum on drug activity is also of clinical interest. We studied the effect of roxithromycin on the opsonizing time of plasma and the oxygen consuming activity of phagocytes in peripheral whole blood that reflects in vivo bacteremia more than isolated serum and granulocytes. Roxithromycin has no effect on the opsonizing activity at any concentrations we examined. At lower concentration (<50μg/ml), roxithromycin does not give any effects on zymosan-stimulated oxygen consumption either. At the highest concentration (200μg/ml) we examined, the antibiotic however decreases it to the extent comparable to that reported in serum-free reconstituted in vitro system. These results indicate that roxithromycin has modulatory effects neither on anti-microbial oxygen metabolism of phagocytes nor on the opsonizing activity of plasma at pharmacological concentration, but is inhibitory on the former at its toxic concentration. On the other hand, serum proteins have no effects on drug toxicity in this context in comparison to in vitro studies (24, 30).

• 長崎大学の論文

著者

• Fujii Yoshito

  Department Of Host-defense Biochemistry Institute Of Tropical Medicine Nagasaki University

• Yoshito Fujii

  Department Of Biochemistry Institute Of Tropical Medicine Nagasaki University

• Kumatori Atsushi

  Department Of Host-defense Biochemistry Institute Of Tropical Medicine Nagasaki University

• Atsushi Kumatori

  Department Of Biochemistry Institute Of Tropical Medicine Nagasaki University

• Nurun Nahr

  Department of Biochemistry, Institute of Tropical Medicine, Nagasaki University

• Nurun Nahr

  Department Of Biochemistry Institute Of Tropical Medicine Nagasaki University

• Faizunnessa Nurun

  Department of Biochemistry, Institute of Tropical Medicine, Nagasaki University

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